Above genes: epigenetics and psychiatry

Epigenetics and methylomics in psychiatry.

P sychiatric genetics is evolving rapidly. No longer are genes thought to directly and by themselves cause psychiatric illnesses. Instead, we now know genes can code for molecules that regulate information processing in behaviorproducing neuronal circuits. When a critical number of molecular abnormalities are present in key brain circuits, individuals with those abnormal circuits are considered...

Epigenetics in Psychiatry

With rapid evolution ongoing in the field of epigenetics, clinicians, hindered by time constraints, are often unable to adequately keep up with the new developments that apply to their patients and practice. Epigenetics in Psychiatry aims to tackle this precise problem. With near absolute completeness, the text covers not only the most recent developments in epigenetics related to psychiatric d...

Epigenetics and Tumor Suppressor Genes

The Social Environment and Epigenetics in Psychiatry 26 CHAPTER

Introduction: social factors, genes, and gene expression programming .....................................................548 How mechanisms of gene regulation “above the genome” contribute to inter-individual differences in behavior ....................................................................................................................549 Overview of epigenetic mechanisms ............

Glucuronidation Enzymes, Genes and Psychiatry

The phase I cytochrome P450 (CYP) isoenzymes have received substantial attention in the pharmacogenetic literature. Researchers are beginning to examine the role of the phase II UDP-glucuronosyltransferase (UGT) enzymes, which produce products that are more water-soluble, less toxic and more readily excreted than the parent compounds. Several reasonsmay have contributed to neglect of UGTs (comp...